{"id":5939,"date":"2024-02-29T18:58:38","date_gmt":"2024-02-29T17:58:38","guid":{"rendered":"https:\/\/spectrumseurope.com\/?p=5939"},"modified":"2025-06-24T08:40:29","modified_gmt":"2025-06-24T06:40:29","slug":"cbd-exposome-de-la-fonction-antioxydante-a-la-photoprotection","status":"publish","type":"post","link":"https:\/\/spectrumseurope.com\/fr\/cbd-exposome-de-la-fonction-antioxydante-a-la-photoprotection\/","title":{"rendered":"CBD & Exposome\u00a0: de la fonction antioxydante \u00e0 la photoprotection"},"content":{"rendered":"\n
\"banniere-anti-ox-photoprotection\"<\/figure>\n\n\n\n

CBD & Exposome\u00a0: de la fonction antioxydante \u00e0 la photoprotection<\/h1>\n\n\n\n

Le cannabidiol module un nombre important de r\u00e9seaux biologiques<\/a> en lien avec la r\u00e9g\u00e9n\u00e9ration de la fonction barri\u00e8re tenant \u00e0 la fois \u00e0 la qualit\u00e9 structurelle du stratum corneum et \u00e0 l\u2019am\u00e9lioration de la r\u00e9ponse anti-inflammatoire. Ce tableau d\u2019une fonction barri\u00e8re multidimensionnelle est compl\u00e9t\u00e9 par la mise en \u00e9vidence d\u2019un potentiel d\u2019action du CBD sur le syst\u00e8me naturel de d\u00e9fense de la peau contre les radicaux libres.<\/p>\n\n\n\n\n\n\n\n

La peau produit naturellement plusieurs mol\u00e9cules antioxydantes pour combattre les esp\u00e8ces r\u00e9actives \u00e0 l\u2019oxyg\u00e8ne afin de prot\u00e9ger les cellules contre les effets du stress oxydatif. L\u2019\u00e9tude r\u00e9alis\u00e9e sur l\u2019Optima CBD XB\u00ae a mis en \u00e9vidence l\u2019activation de NMRAL2P (NmrA Like Redox Sensor 2), un pseudog\u00e8ne cible de l\u2019action de NRF2. Il est associ\u00e9 avec la production de NQO1 (quinone dehydrogenase), qui elle, intervient dans l\u2019activit\u00e9 antioxydante. Optima CBD XB\u00ae r\u00e9gule \u00e9galement l\u2019expression du g\u00e8ne ALDH5A (Aldehyde Dehydrogenase 5 Family Member A1) connu pour d\u00e9toxifier les ald\u00e9hydes g\u00e9n\u00e9r\u00e9s, par exemple, lors de la peroxydation lipidique. Le potentiel d\u2019action antioxydante de l\u2019actif \u00e0 0,1% a \u00e9t\u00e9 confirm\u00e9 par une \u00e9tude en prot\u00e9omique sur la mesure de NQO1 et r\u00e9v\u00e9lant une augmentation de plus de 100 % en comparaison avec l\u2019excipient. De fa\u00e7on corollaire, l\u2019\u00e9tude g\u00e9nomique sur Optima CBD XB\u00ae a mis au jour une propri\u00e9t\u00e9 remarquable de notre mol\u00e9cule sur la gestion de la m\u00e9lanine dans la peau.<\/p>\n\n\n\n

Nous savons que la m\u00e9lanine a pour fonction principale de prot\u00e9ger notre peau contre les UV. Les grains de m\u00e9lanine pr\u00e9sents dans les k\u00e9ratinocytes forment un microparasol au-dessus du noyau (r\u00e9gion supra nucl\u00e9aire) capable d\u2019absorber les UV, \u00e9vitant ainsi que l\u2019ADN ne soit endommag\u00e9. La m\u00e9lanine poss\u00e8de \u00e9galement un fort pouvoir antioxydant, permettant de lutter contre les radicaux libres et le stress oxydatif induit lors d\u2019une exposition prolong\u00e9e au soleil.<\/p>\n\n\n\n

Afin de jouer son r\u00f4le, la m\u00e9lanine produite dans les m\u00e9lanocytes \u00e0 l\u2019int\u00e9rieur de v\u00e9sicules appel\u00e9es les m\u00e9lanosomes, doit \u00eatre transf\u00e9r\u00e9e vers les k\u00e9ratinocytes voisins. Ces m\u00e9lanomes se d\u00e9gradent ensuite naturellement lors du processus de diff\u00e9renciation des k\u00e9ratinocytes par la pr\u00e9sence d\u2019enzymes (dont cathepsin V). L\u2019efficacit\u00e9 protectrice optimale de la pigmentation constitutive r\u00e9side ainsi dans le bon \u00e9quilibre entre la production de m\u00e9lanine dans les m\u00e9lanocytes et la d\u00e9gradation des m\u00e9lanomes dans les k\u00e9ratinocytes. En stimulant l\u2019expression g\u00e8nes impliqu\u00e9s dans le transfert des m\u00e9lanosomes – CD1A , POGLUT 1 (protein O-glucosyltransferase 1) – ou du g\u00e8ne codant pour la cathepsin V (CTSV), Optima CBD XB\u00ae favorise le bon \u00e9quilibre du cycle physiologique de la m\u00e9lanine pour une protection optimale.<\/p>\n\n\n\n

Au total, cette fonction antioxydante combin\u00e9e \u00e0 la capacit\u00e9 \u00e0 favoriser le transfert de la m\u00e9lanine dans les k\u00e9ratinocytes, se pense comme une v\u00e9ritable fonction biologique transverse de l\u2019Optima CBD XB\u00ae<\/a>, promoteur d\u2019une fonction barri\u00e8re multi-dimensionnelle. La mol\u00e9cule associant r\u00e9g\u00e9n\u00e9ration du stratum corneum<\/a>, am\u00e9lioration de la r\u00e9ponse anti-inflammatoire<\/a>, photoprotection et induction du syst\u00e8me de d\u00e9fense antioxydant, se positionne ainsi comme une proposition int\u00e9grative ou holistique dans la formulation de soins de jours, de soins antipollution, ou de soins solaires \u2013 sans parler \u00e9videmment des formules protectrices des peaux sensibles et r\u00e9actives.<\/p>\n","protected":false},"excerpt":{"rendered":"

CBD & Exposome\u00a0: de la fonction antioxydante \u00e0 la photoprotection Le cannabidiol module un nombre important de r\u00e9seaux biologiques en lien avec la r\u00e9g\u00e9n\u00e9ration de la fonction barri\u00e8re tenant \u00e0 la fois \u00e0 la qualit\u00e9 structurelle du stratum corneum et \u00e0 l\u2019am\u00e9lioration de la r\u00e9ponse anti-inflammatoire. Ce tableau d\u2019une fonction barri\u00e8re multidimensionnelle est compl\u00e9t\u00e9 par<\/p>\n","protected":false},"author":1,"featured_media":5932,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,67,47,40],"tags":[45,123,124],"class_list":["post-5939","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites","category-fa-f5","category-fa-parent","category-fa-pb","tag-cbd","tag-fonctionbarriere","tag-skinscience"],"yoast_head":"\nCBD & Exposome\u00a0: de la fonction antioxydante \u00e0 la photoprotection - Spectrums Europe<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/spectrumseurope.com\/fr\/cbd-exposome-de-la-fonction-antioxydante-a-la-photoprotection\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CBD & Exposome\u00a0: de la fonction antioxydante \u00e0 la photoprotection - Spectrums Europe\" \/>\n<meta property=\"og:description\" content=\"CBD & Exposome\u00a0: de la fonction antioxydante \u00e0 la photoprotection Le cannabidiol module un nombre important de r\u00e9seaux biologiques en lien avec la r\u00e9g\u00e9n\u00e9ration de la fonction barri\u00e8re tenant \u00e0 la fois \u00e0 la qualit\u00e9 structurelle du stratum corneum et \u00e0 l\u2019am\u00e9lioration de la r\u00e9ponse anti-inflammatoire. 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